Search results for "Chylomicron remnant"

showing 1 items of 1 documents

Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor

2007

LPL mediates the uptake of lipoproteins into different cell types independent of its catalytic activity. The mechanism of this process and its physiological relevance are not clear. Taking into account the importance of the endothelial barrier for lipoprotein uptake, in vitro studies with primary aortic endothelial cells from wild-type and low density lipoprotein receptor (LDLR)-deficient (LDLR(-/-)) mice were performed. Addition of LPL almost doubled the uptake of LDL into wild-type cells. However, there was virtually no LPL-mediated change of LDL uptake into LDLR(-/-) cells. Upregulation of LDLR by lipoprotein-deficient serum/lovastatin in wild-type cells resulted in a 7-fold increase of …

Malemedicine.medical_specialtyendotheliumQD415-436BreedingBiochemistrylipidschemistry.chemical_compoundMiceEndocrinologyChylomicron remnantInternal medicinemedicineAnimalscardiovascular diseasesMuscle SkeletalCells CulturedLipoprotein lipaseCholesteroldigestive oral and skin physiologyEndothelial Cellsfood and beveragesnutritional and metabolic diseasescholesterolBiological TransportCell BiologyDietary FatsDietLipoproteins LDLMice Inbred C57BLLipoprotein LipaseEndocrinologychemistryBiochemistryReceptors LDLLow-density lipoproteinLDL receptortransportFemaleProteoglycanslipids (amino acids peptides and proteins)Lovastatinatherosclerosislow density lipoproteinmedicine.drugChylomicronLipoproteinJournal of Lipid Research
researchProduct